Desmond David Hume was the lone resident of the Swan at the time of the Flight 815 crash. Locke, Kate, and Jack discovered him there 44 days after the crash, after they had blown open the Hatch. After his failed attempt to leave the Island on his sailboat, Desmond joined the camp of survivors. Following the destruction of the Swan, Desmond gained a mysterious ability to see flashes of the future, with which he predicted Charlie's imminent death. During the helicopter ride to the freighter, Desmond's consciousness from the past (1996) began drifting to the present (2004) until Desmond made contact with his constant, his long-lost love, Penelope Widmore. On December 31, 2004, after over three years on the Island, Desmond was rescued along with the Oceanic Six by Penelope herself.

John Locke is one of the middle section survivors of Oceanic Flight 815. His paralysis was immediately healed upon crashing on the Island, which has ultimately led him to believe he has some sort of special connection to the Island. He is sometimes shown in opposition to Benjamin Linus, although they share several traits including the ability to commune with Jacob. Seen as antithetical to Jack Shephard, he and Jack are philosophical opposites and used to share leadership among the survivors. Locke had eventually separated himself from most of the camp, and led the group of his supporters to the Barracks, where they became the first Island inhabitants to be attacked by freighter mercenaries. Locke has recently established contact with Jacob through Christian, who told him about a way to ultimately save the Island. After the Island has been moved, Locke assumes leadership of the Others.